Endocrine Abstracts

Worldwide numerous active individuals take phosphodiesterase type 5 inhibitors (PDE-5i), furthermore, to our knowledge, the effects of these drugs on hormone secretion has not been adequately investigated. In particular, considering that a) PDE-5i influence NO bioavailability, b) NO is one of the mediators of the hypothalamus–pituitary–adrenal (HPA) axis response to stress, and, c) physical exercise-related stress activate HPA axis, we investigated whether PDE-5i inf...